Reliable evidence syntheses using systematic review methodology are essential for making reliable decisions. To assess the certainty of a body of evidence included in a systematic review, the GRADE Working Group on Grading of Recommendations Assessment, Development and Evaluation has developed an approach that, in a four-part video series presented by Laura Chiavaroli, MSc, PhD Department of Nutritional Sciences, University of Toronto. This video examines the. Background Assessing the certainty of the evidence is a key element of any systematic review. The aim of this meta-epidemiological study was to understand the frequency and ways in which certainty is obtained. This review was carried out at the request of the Swedish Agency for Health Technology Assessment and Social Services Evaluation (SBU) and a Swedish version of the report can be found in S. The relationship between the Swedish version and the current English version is described in S and the SBU permit is, Introduction. Systematic reviews SRs, evidence-based medicine and clinical guidelines bring together reliable information by systematically capturing, analyzing and transferring research findings into clinical, management and policy arenas. Therefore, the results of several works in the medical literature on related topics are evaluated, GRADE initially provided a formal definition of certainty of evidence as "the degree of our confidence that effect estimates are correct" in the context of systematic reviews and health technology assessment, which suggests that we are assessing our certainty in point estimates of the effect, or 'the measure of our confidence that the,